Rat Lipopolysaccharides/lipooligosaccharide,LPS/LOS ELISA Kit

Information

Name

  • Rat Lipopolysaccharides/lipooligosaccharide,LPS/LOS ELISA Kit

Size

  • 96T

Catalog No

  • E0756Ra

Price

  • 721 €

Extended details

Gene

  • Bacterial pathogen lipopolysaccharides (LPS) are the major outer surface membrane components present in almost all Gram-negative bacteria and act as extremely strong stimulators of innate or natural immunity in diverse eukaryotic species ranging from insects to humans
  • LPS consist of a poly- or oligosaccharide region that is anchored in the outer bacterial membrane by a specific carbohydrate lipid moiety termed lipid A
  • The lipid A component is the primary immunostimulatory center of LPS
  • With respect to immunoactivation in mammalian systems, the classical group of strongly agonistic (highly endotoxin) forms of LPS has been shown to be comprised of a rather similar set of lipid A types
  • In addition, several natural or derivative lipid A structures have been identified that display comparatively low or even no immunostimulation for a given mammalian species
  • Some members of the latter more heterogeneous group are capable of antagonizing the effects of strongly stimulatory LPS/lipid A forms
  • Agonistic forms of LPS or lipid A trigger numerous physiological immunostimulatory effects in mammalian organisms, but--in higher doses--can also lead to pathological reactions such as the induction of septic shock
  • Cells of the myeloid lineage have been shown to be the primary cellular sensors for LPS in the mammalian immune system
  • During the past decade, enormous progress has been obtained in the elucidation of the central LPS/lipid A recognition and signaling system in mammalian phagocytes
  • According to the current model, the specific cellular recognition of agonistic LPS/lipid A is initialized by the combined extracellular actions of LPS binding protein (LBP), the membrane-bound or soluble forms of CD14 and the newly identified Toll-like receptor 4 (TLR4)*MD-2 complex, leading to the rapid activation of an intracellular signaling network that is highly homologous to the signaling systems of IL-1 and IL-18
  • The elucidation of structure-activity correlations in LPS and lipid A has not only contributed to a molecular understanding of both immunostimulatory and toxic septic processes, but has also re-animated the development of new pharmacological and immuno-stimulatory strategies for the prevention and therapy of infectious and malignant diseases.

About

  • Rats are used to make rat monoclonal anti mouse antibodies
  • There are less rat- than mouse clones however
  • Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.

Properties

  • E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays,E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays

Sample Types

  • serum, blood, plasma, saliva, urine, and other related tissue liquid

Test

  • ELISA Enzyme-linked immunosorbent assays Code 90320007 SNOMED

Platform

  • Microplate Reader

Latin name

  • Rattus norvegicus

Object tested

  • Rat